文章基本信息
- 标题：Clinical Features of Retinopathy in Chronic Hepatitis B Patients With Treated With Peginterferon
- 本地全文：下载
- 作者：Kwon, Yong Dae ; Lim, Ji Won
- 期刊名称：Journal of the Korean Ophthalmological Society
- 印刷版ISSN：0378-6471
- 出版年度：2011
- 卷号：52
- 期号：1
- 页码：41-45
- DOI：10.3341/jkos.2011.52.1.41
- 语种：Korean
- 出版社：The Korean Ophthalmological Society
- 摘要：Purpose
To evaluate the clinical features of retinopathy in chronic hepatitis B patients treated with peginterferon.
MethodsChronic hepatitis B patients treated with peginterferon were evaluated during regular routine ophthalmic examinations including fundus examination before and during the 1-year follow-up after treatment. A total of 88 patients were included in the study.
ResultsRetinopathy developed in 11 (12.5%) out of 88 patients at a mean of 7 weeks after initiation of treatment. Peginterferon treatment was continued in all patients and retinal abnormalities including cotton wool spot, retinal hemorrhage and microaneurysm resolved without visual impairment. The incidence of hypertension between the retinopathy group and the group without retinopathy was significantly different ( P = 0.020).
ConclusionsThe incidence of retinopathy with peginterferon in chronic hepatitis B patients was low and the prognosis was benign. Thus, routine screening for peginterferon retinopathy is not necessary.
- 关键词：Chronic hepatitis B; Pegylated interferon; Retinopathy
