文章基本信息
- 标题：Comparison of the Effects Between Bevacizumab and Mitomycin C on the Survival of Fibroblasts
- 本地全文：下载
- 作者：Kim, Sin Hoo ; Kim, Jae Woo
- 期刊名称：Journal of the Korean Ophthalmological Society
- 印刷版ISSN：0378-6471
- 出版年度：2011
- 卷号：52
- 期号：3
- 页码：345-349
- DOI：10.3341/jkos.2011.52.3.345
- 语种：Korean
- 出版社：The Korean Ophthalmological Society
- 摘要：Purpose
To compare the antiproliferative effects between bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), and mitomycin C in human Tenon's capsule fibroblasts.
MethodsPrimarily cultured human Tenon's capsule fibroblasts were exposed to 0, 25, 50, 100, and 200 µg/ml bevacizumab and mitomycin C, and incubated for 5 days. Cellular survival and production of nitric oxide were assessed by MTT assay and Griess assay, respectively.
ResultsBevacizumab showed antiproliferative effects only at high concentrations (200 µg/ml) and revealed much less effect on the cellular survival compared to mitomycin C. In addition, bevacizumab did not affect the production of nitric oxide.
ConclusionsThe antiproliferative effect of bevacizumab is much lower than mitomycin C in human Tenon's capsule fibroblasts.
- 关键词：Antiproliferation; Bevacizumab; Fibroblast; Mitomycin C
