To evaluate the efficacy of intravitreal tissue plasminogen activator (tPA) with C₃F₈ injection for branch retinal vein occlusion (BRVO) involving fovea.

Seven patients (7 eyes) presenting with subfoveal hemorrhage caused by BRVO were treated with an intravitreal tPA and C₃F₈ injection. We assessed the visual acuity (VA) and foveal thickness measured with optical coherence tomography.

The mean duration of symptoms before surgery was 5.42±1.90 weeks. The mean logMAR VA improved from 1.14±0.19 at baseline to 0.87±0.34 at one week and 0.30±0.32 at six months. The mean foveal thickness decreased from 564.421±186.88 µm at baseline to 483.14±275.06 µm at one week and 353.28±152.99 µm at six months. There was no adverse effect related to the treatment.

Intravitreal tPA with C₃F₈ injection may be an effective treatment for resolving macular edema with subfoveal hemorrhage and improving the VA in recently developed BRVO.