To evaluate the inhibitory effect of tranilast on formation of corneal haze using the Pentacam® after photorefractive keratectomy (PRK).

A prospective, randomized, paired eye study was performed. A total of 60 eyes from 30 patients were enrolled in the present study. Eyes were categorized as myopic eyes <-5 D and ≥-5 D. Patients undergoing PRK were randomized to receive tranilast in one eye and no medication in the contralateral eye. Three months postoperatively, corneal haze was measured with the Pentacam® and compared between the 2 groups.

Statistical differences were not found in preoperative data in the tranilast or control groups (all P > 0.05). There was a strong decreasing density trend from the apex to the 3 mm radius in both groups ( P < 0.05). However, postoperative corneal haze in the tranilast group was similar to the control group ( P > 0.05).

The use of tranilast after PRK did not inhibit corneal opacity. Additionally, Pentacam® can provide a useful objective measure of corneal haze.