文章基本信息
- 标题：Effects of Intravitreal Amniotic Membrane Injection in a Rat Model of Choroidal Neovascularization
- 本地全文：下载
- 作者：Lee, Jong Hyun ; Chung, Jae Lim ; Hong, Samin 等
- 期刊名称：Journal of the Korean Ophthalmological Society
- 印刷版ISSN：0378-6471
- 出版年度：2008
- 卷号：49
- 期号：7
- 页码：1154-1158
- DOI：10.3341/jkos.2008.49.7.1154
- 语种：Korean
- 出版社：The Korean Ophthalmological Society
- 摘要：Purpose
To evaluate the effects of an intravitreal amniotic membrane (AM) injection on a rat model of laser-induced choroidal neovascularization (CNV).
MethodsIntravitreal injection of AM (12.5 µg/mL) into the left eyes and phosphate-buffered saline into the fellow eyes of 15 rats was performed immediately after laser injury. At week 2, after angiography, the rats were sacrificed, and histopathologic analysis was performed. Angiographic and histopathologic assessments of the effects of AM injection on CNV growth were compared between the two groups.
ResultsCNV thickness was found to have increased more in the AM treatment group (141.54±8.12 µm) than in the experimental control group (65.23±16.90 µm) ( p =0.010).
ConclusionsIntravitreal AM injection demonstrated histopathologic pro-angiogenic properties in a rat model of CNV.
- 关键词：Amniotic membrane; Angiogenesis; Choroidal neovascularization
