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  • 标题:A clinical study of systemic lupus erythematosus in children
  • 本地全文:下载
  • 作者:Kim, Ji Tae ; Nam, Young Mee ; Lee, Jae Seung
  • 期刊名称:Korean Journal of Pediatrics
  • 印刷版ISSN:1738-1061
  • 出版年度:2007
  • 卷号:50
  • 期号:1
  • 页码:74-78
  • DOI:10.3345/kjp.2007.50.1.74
  • 语种:Korean
  • 出版社:The Korean Pediatric Society
  • 摘要:Purpose

    Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with complex clinical manifestations. It probably involves genetic, environmental and immunologic factors. In this study, we investigated the clinical manifestations, laboratory findings and prognosis of pediatric SLE to aid clinical care of pediatric SLE.

    Methods

    The data of 45 patients who were diagnosed as pediatric SLE in Severance Children's Hospital from Jan. 1996 to Dec. 2005 were analysed retrospectively.

    Results

    The mean age at diagnosis was 10.8 (0-15) years old. And the ratio of male to female patients was 1:4. The initial manifestations were facial edema (51.1 percent), malar rash (44.4 percent), and fever (28.9 percent). The ANA (97.8 percent), anti-ds DNA antibody (82.2 percent), lupus nephritis (71.1 percent), malar rash (71.1 percent), and cytopenia (66.7 percent) were the most common findings among the classification criteria by ACR (American College of Rhematology, 1997).

    Conclusion

    Clinical manifestations and prognosis are various in pediatric SLE. Intensive studies of SLE in children should be continued for more effective treatment.

  • 关键词:Systemic lupus erythematosus; Children; Adolescent
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