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文章基本信息

  • 标题:Noninvasive diagnosis of pediatric nonalcoholic fatty liver disease
  • 本地全文:下载
  • 作者:Yang, Hye Ran
  • 期刊名称:Korean Journal of Pediatrics
  • 印刷版ISSN:1738-1061
  • 出版年度:2013
  • 卷号:56
  • 期号:2
  • 页码:45-51
  • DOI:10.3345/kjp.2013.56.2.45
  • 语种:English
  • 出版社:The Korean Pediatric Society
  • 摘要:

    Because nonalcoholic steatohepatitis can progress towards cirrhosis even in children, early detection of hepatic fibrosis and accurate diagnosis of nonalcoholic fatty liver disease (NAFLD) are important. Although liver biopsy is regarded as the gold standard of diagnosis, its clinical application is somewhat limited in children due to its invasiveness. Noninvasive diagnostic methods, including imaging studies, biomarkers of inflammation, oxidative stress, hepatic apoptosis, hepatic fibrosis, and noninvasive hepatic fibrosis scores have recently been developed for diagnosing the spectrum of NAFLD, particularly the severity of hepatic fibrosis. Although data and validation are still lacking for these noninvasive modalities in the pediatric population, these methods may be applicable for pediatric NAFLD. Therefore, noninvasive imaging studies, biomarkers, and hepatic fibrosis scoring systems may be useful in the detection of hepatic steatosis and the prediction of hepatic fibrosis, even in children with NAFLD.

  • 关键词:Nonalcoholic fatty liver disease; Fibrosis; Diagnosis; Obesity; Child
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