首页    期刊浏览 2024年11月24日 星期日
登录注册

文章基本信息

  • 标题:Clinical, endocrinological and radiological courses in patients who was initially diagnosed as idiopathic central diabetes insipidus
  • 本地全文:下载
  • 作者:Chung, Seung Joon ; Lee, Seong Yong ; Shin, Choong Ho
  • 期刊名称:Korean Journal of Pediatrics
  • 印刷版ISSN:1738-1061
  • 出版年度:2007
  • 卷号:50
  • 期号:11
  • 页码:1110-1115
  • DOI:10.3345/kjp.2007.50.11.1110
  • 语种:Korean
  • 出版社:The Korean Pediatric Society
  • 摘要:Purpose

    Idiopathic central diabetes insipidus (CDI) is defined in CDI patients without definite etiology. Some patients initially diagnosed as idiopathic CDI progressed to organic causes. We reviewed clinical, endocrinological, and radiological courses of 20 patients who was initially diagnosed as idiopathic CDI, to assess the predicting factors for progression to brain tumors.

    Methods

    We reviewed the medical data and followed up their clinical courses in 20 CDI patients who had no definite organic etiology, such as malformation, tumor, at the time of diagnosis.

    Results

    Our study included 15 males and 5 females. Mean age of CDI diagnosis was 7.8±3.6 (2.1-14.7) years. Mean follow-up duration was 8.6±5.1 (1.5-18) years. Six (30%) patients were diagnosed as brain tumor during follow-up. Ten (50%) of 20 patients had growth hormone deficiency. Multiple pituitary hormone deficiencies were found more frequently in brain tumor patients than idiopathic patients (60% vs 7%, P =0.037). Pituitary stalk thickening (PST) and loss of posterior pituitary signal were observed in 9 patients (47%), respectively. The newly development of PST was observed in patients diagnosed as brain tumor.

    Conclusion

    About 30% of idiopathic CDI patients progress to organic disease such as germ cell tumor or histiocytosis. If there are multiple anterior pituitary hormone deficiency or newly development of PST, more close and careful follow-up is needed.

  • 关键词:Central diabetes insipidus; Growth hormone deficiency; Cerebral tumor; Germinoma; Langerhans cell histiocytosis
国家哲学社会科学文献中心版权所有