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  • 标题:Basal cell nevus syndrome (gorlin syndrome) confirmed by PTCH mutations and deletions
  • 本地全文:下载
  • 作者:Kim, Hee Moon ; Lee, Chul Hee ; Kim, Sung Koo
  • 期刊名称:Korean Journal of Pediatrics
  • 印刷版ISSN:1738-1061
  • 出版年度:2007
  • 卷号:50
  • 期号:8
  • 页码:789-793
  • DOI:10.3345/kjp.2007.50.8.789
  • 语种:English
  • 出版社:The Korean Pediatric Society
  • 摘要:

    Basal cell nevus syndrome (BCNS), also known as Gorlin syndrome, is a rare autosomal dominant disorder characterized by variable manifestations, including multiple basal cell carcinomas, odontogenic keratocysts of the jaw, skeletal anomalies including scoliosis and bifid ribs, palmar and plantar pits, calcification of the falx cerebri, and biparietal frontal bossing. We report a case of a 9-year-old boy with the clinical features of basal cell nevus syndrome, in which a PTCH gene mutation was confirmed by DNA testing.

  • 关键词:Basal cell nevus syndrome; Odontogenic keratocyst; PTCH mutation
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