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  • 标题:A case of idiopathic renal hypouricemia
  • 本地全文:下载
  • 作者:Han, Moon Hee ; Park, Sang Uk ; Kim, Deok-Soo
  • 期刊名称:Korean Journal of Pediatrics
  • 印刷版ISSN:1738-1061
  • 出版年度:2007
  • 卷号:50
  • 期号:5
  • 页码:489-492
  • DOI:10.3345/kjp.2007.50.5.489
  • 语种:English
  • 出版社:The Korean Pediatric Society
  • 摘要:

    Idiopathic renal hypouricemia is a disorder characterized by impaired urate handling in the renal tubules. This disease usually produces no symptoms, but hematuria, uric acid nephrolithiasis or acute renal failure may develop. A defect in the SLC22A12 gene, which encodes the human urate transporter, is the known major cause of this disorder. We describe a 10-month-old boy with idiopathic renal hypouricemia. He was diagnosed with transient pseudohypoaldosteronism at admission, but hypouricemia was accidentally found through follow-up study. By gene analysis, his diagnosis was confirmed to idiopathic renal hypouricemia. In addition, we report a mutation in the human urate transporter 1 (hURAT1) gene identified in his family.

  • 关键词:Human urate transporter 1 (hURAT1) gene; Idiopathic renal hypouricemia; SLC22A12 gene; Transient pseudohypoaldosteronism
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