文章基本信息

标题：The Effect of COX-2 Inhibitor on the Expression of MMP-13 during Early Fracture Healing Phase in Rats
本地全文：下载
作者：Kang, Ki Ser ; Lee, Han Jun ; Lee, Jae Sung 等
期刊名称：Journal of the Korean Fracture Society
印刷版ISSN：1225-1682
出版年度：2009
卷号：22
期号：1
页码：45-50
DOI：10.12671/jkfs.2009.22.1.45
语种：English
出版社：The Korean Fracture Society
摘要：Purpose
This study investigated the effect of COX-2 inhibitor on the expression of MMP-13 in the healing process of fracture.
Materials and Methods
Adult Sprague-Dawley rats were divided into two groups of twenty five rats each. Unilateral femoral shaft fractures were created artificially under displacement in all two groups. COX-2 inhibitor was only given to the experimental group from the postoperative day 1. At 2 weeks after fracture the rats were sacrificed and the callus from each group was used for histologic examination and real time RT-PCR for MMP-13 expression.
Results
Histologically, proliferation of osteoblasts and formation of osteoid was less abundant in the experimental group. In real time RT-PCR, the mean expression of MMP-13 is 2.84±2.50 in the control group compared with 1.16±1.05 in the experimental group
Conclusion
In the early stage of fracture healing, COX-2 inhibitor suppress the expression of MMP-13.
关键词：Fracture; Healing; MMP-13; COX-2 inhibitor