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  • 标题:Change of Circulating Leptin, Adiponectin, Resistin, and Visfatin Level after Treatment of Patients with Active Inflammatory Bowel Disease
  • 本地全文:下载
  • 作者:Hwangbo, Young ; Kim, Hyo Jong ; Shim, Jaejun
  • 期刊名称:Intestinal Research
  • 印刷版ISSN:1598-9100
  • 电子版ISSN:2288-1956
  • 出版年度:2010
  • 卷号:8
  • 期号:2
  • 页码:151-161
  • DOI:10.5217/ir.2010.8.2.151
  • 语种:Korean
  • 出版社:Korean Association for the Study of Intestinal Diseases
  • 摘要:Background/Aims

    The aim of this study was to evaluate the change in circulating levels of adipokines, including leptin, adiponectin, resistin, and visfatin, after induction therapy of patients with active inflammatory bowel disease (IBD).

    Methods

    We prospectively evaluated 20 patients with Crohn's disease (CD) and 14 patients with ulcerative colitis (UC) who received induction therapy. The disease activity, body mass index (BMI), and C-reactive protein (CRP) and serum adipolines levels were checked before treatment and 10 weeks after treatment.

    Results

    After induction therapy, significant reduction of disease activity was noted in patients with CD (CD activity index, 267.9±73.7 vs. 50.8±36.5, P <0.001) and patients with UC (Mayo score, 9.8±2.2 vs. 1.4±1.6, P <0.001). The mean serum leptin, adiponectin, resistin, and visfatin levels were 4.0±2.7 ng/mL and 4.4±2.3 ng/mL ( P =0.323), 27.0±20.5 µg/mL and 33.8±26.5µg/mL ( P =0.084), 9.0±4.0 ng/mL and 10.2±3.2 ng/mL ( P =0.108), and 4.6±3.7 ng/mL and 2.5±4.1 ng/mL ( P =0.046) before and after infliximab treatment, respectively. No significant correlation between the changes in BMI, CRP level, or the clinical indices of activity and alterations of the measured adipokines was demonstrated.

    Conclusions

    The serum levels of leptin, adiponectin, and resistin showed no significant alterations, whereas the serum visfatin level decreased significantly after induction therapy, suggesting a possible pro-inflammatory property of visfatin and a role as a marker of successful therapy of IBD.

  • 关键词:Inflammatory bowel disease; Leptin; Adiponectin; Resistin; visfatin
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