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  • 标题:Disseminated Hemangioblastoma of the Central Nervous System without Von Hippel-Lindau Disease
  • 本地全文:下载
  • 作者:Chung, Sun-Yoon ; Jeun, Sin-Soo ; Park, Jae-Hyun
  • 期刊名称:Brain Tumor Research and Treatment
  • 印刷版ISSN:2288-2405
  • 出版年度:2014
  • 卷号:2
  • 期号:2
  • 页码:96-101
  • DOI:10.14791/btrt.2014.2.2.96
  • 语种:English
  • 出版社:The Korean Brain Tumor Society and The Korean Society for Neuro-Oncology
  • 摘要:

    Hemangioblastoma (HB) of the central nervous system may occur sporadically or in association with von Hippel-Lindau (VHL) disease. Disseminated HB means malignant spread of the original primary HB without local recurrence at surgically resected site. It has been rarely reported previously, and rarer especially without VHL gene mutation. We report a case of disseminated HB without VHL disease. A 59-year-old man underwent a surgery for total removal of a cerebellar HB. From five years after the surgery, multiple dissemination of HB was identified intracranially and he subsequently underwent cyberknife radiosurgery. The lesions got smaller temporarily, but they soon grew larger. Nine years after the initial surgery for cerebellar HB, he showed severe back pain. His magnetic resonance image of spine revealed intradural extramedullary mass at T6-7 level. Complete surgical removal of the mass was performed and the pathological diagnosis was identical to the previous one. He had no evidence of VHL disease. And there was no recurrence of the tumor at the site of the original operation. The exact mechanism of dissemination is unknown, but the surgeon should be cautious of tumor cell spillage during surgery and prudently consider the decision to perform ventriculo-peritoneal shunt. In addition, continuous follow-up for recurrence or dissemination is necessary for patients even who underwent complete removal of cerebellar HB.

  • 关键词:Hemangioblastoma; Von Hippel-Lindau disease; Central nervous system
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