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  • 标题:Increase in concentration of soluble HLA-G in high-quality embryos after intracytoplasmic sperm injection
  • 本地全文:下载
  • 作者:Heidari, Mohammad Hassan ; Novin, Marefat Ghaffari ; Ahmadi, Farzaneh
  • 期刊名称:Anatomy & Cell Biology
  • 印刷版ISSN:2093-3665
  • 出版年度:2011
  • 卷号:44
  • 期号:4
  • 页码:331-336
  • DOI:10.5115/acb.2011.44.4.331
  • 语种:English
  • 出版社:Anatomy and Cell Biology
  • 摘要:

    Non-invasive methods are normally preferred to conventional invasive methods when selecting suitable embryos to improve pregnancy rates after assisted reproduction techniques. One of the most recognized non-invasive methods is to examine the supernatants of embryo culture media. Soluble human leukocyte antigen, class I, G (sHLA-G) antigen is a non-classical class I molecule that has been widely considered as a marker of pregnancy failure or implantation success. In the current study of some Iranian patients, we examined the concentration of sHLA-G at different time points after intracytoplasmic sperm injection and compared the rates to the morphology and quality of the selected embryos. We showed that the concentration of sHLA-G increases over time in high-quality embryos. We conclude that there is a positive relationship between morphology, quality, and sHLA-G concentration. We suggest that this relationship can be used to increase the chance of a successful pregnancy.

  • 关键词:HLA antigen; Assisted reproductive techniques; Intracytoplasmic sperm injections
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