Dermatofibroma is a common benign dermal tumor characterized by a proliferation of fibroblast-like spindle cells. It is commonly localized on the skin of extremities and presents as a slow growing solitary nodule. To our knowledge, the occurrence of dermatofibroma in the oral cavity is rare. Herein, we report a rare case of dermatofibroma on the lower lip.

A 60-year-old woman presented with a slow growing mass that measured 1 × 0.8 cm in diameter on the lower lip. The mass was surgically excised with clear margins.

Histologically, the mass was characterized by a nodular tumor composed of collagen bundles, fibroblasts, and histiocytes, which were findings consistent with dermatofibroma. The postoperative course was uneventful without any complications.

When evaluating nodular tumors of the oral area, dermatofibroma should be considered in the differential diagnosis.