文章基本信息

标题：The effects of bone regeneration in rabbit calvarial defect with particulated and block type of hydroxyapatite
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作者：Gu, Sun-Ja ; Sohn, Joo-Yeon ; Lim, Hyun-Chang 等
期刊名称：The Journal of the Korean Academy of Periodontology
印刷版ISSN：0250-3352
出版年度：2009
卷号：39
期号：3
页码：321-329
DOI：10.5051/jkape.2009.39.3.321
语种：Korean
出版社：Korean Academy of Periodontology
摘要：Purpose
The purpose of this study was to evaluate the bone regeneration of particulated hydroxyapatite(HA) and block type of hydroxyapatite graft in rabbit calvarial defects.
Methods
An 8 mm calvarial circular defects were created in sixteen young adult New Zealand white male rabbits (weight 3.0~3.5 kg). Each defects were filled with Bio-Oss, particulated HA and block type HA. Sham surgery control defects were filled with blood clots. The specimens were harvested at 4 weeks and 8 weeks for histologic and histomorphometric evaluation.
Results
Histomorphometric analysis demonstrated statistical differences in defect closure, new bone formation, and bone density of the four groups. Block type of HA group showed increased bone formation and bone density at 4 weeks and 8 weeks compared with Bio-Oss group or sham surgery control group(p<0.05).
Conclusions
Block type of HA is an effective material for osteoconduction in rabbit calvarial defects, which may acts as a guide in use of these products in human application.
关键词：Bone regeneration; bone substitutes; Hydroxyapatites