This study was aimed to evaluate the effect of the Freeze Dried Bone Allograft and Demineralized Bone Matrix on osseous regeneration in the rat calvarial defects.

Eight mm critical-sized calvarial defects were created in the 80 male Sprague-Dawley rats. The animals were divided into 4 groups of 20 animals each. The defects were treated with Freeze Dried Bone Allograft(SureOss™), Demineralized Bone Matrix(ExFuse™ Gel, ExFuse™ Putty), or were left untreated for sham-surgery control and were evaluated by histologic and histomorphometric parameters following a 2 and 8 week healing intervals. Statistical analysis was done between each groups and time intervals with ANOVA and paired t-test.

Defect closure, New bone area, Augmented area in the SureOss™, ExFuse™ Gel, ExFuse™ Putty groups were significantly greater than in the sham-surgery control group at each healing interval( P < 0.05). In the New bone area and Defect closure, there were no significant difference between experimental groups. Augmented area in the ExFuse™ Gel, ExFuse™ Putty groups were significantly greater than SureOss™ group at 2weeks( P < 0.05), however there was no significant difference at 8 weeks.

All of SureOss™, ExFuse™ Gel, ExFuse™ Putty groups showed significant new bone formation and augmentation in the calvarial defect model.