期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2015
卷号：112
期号：1
页码：238-243
DOI：10.1073/pnas.1414422112
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：SignificancePneumonia caused by bacterial coinfection with influenza virus is the leading cause of mortality in influenza pandemics. TGF-{beta} is known to be activated by influenza virus. In this study we demonstrated that cellular adhesins for bacteria, such as fibronectin and 5 integrin, are up-regulated in influenza viral infection. Inhibition of TGF-{beta} impeded the up-regulation of these cellular adhesins and also influenza viral-enhanced bacterial adherence. In addition, we found that influenza viral-promoted bacterial adherence was dependent on bacterial fibronectin-binding protein. The results indicate that up-regulated expression of cellular adhesins by TGF-{beta
关键词：influenza A virus ; TGF-beta ; coinfection ; fibronectin binding protein ; bacterial adherence
