摘要：Authors Blandine Doornaert , Annick Pichard Institut national de l’environnement et des risques industriels (INERIS), Unité « Évaluation toxicologique des substances chimiques » (ETSC), Département des risques chroniques (DRC), Parc technologique ALATA, 60550 Verneuil-en-Halatte Key words: carcinogens, environmental, dose-response relationship, drug, polycyclic hydrocarbons, aromatic, toxicological reference values, toxic equivalent, factor risk assessment Page(s) : 205-20 Published in: 2005 Assessment of the risks from exposure to polycyclic aromatic hydrocarbons (PAHs) is particularly difficult as the population is always exposed to mixtures of PAHs, frequently combined with other chemicals. The aim of this work is to review the various possible approaches to evaluating the dose-response relations between PAH exposures and their carcinogenic effects and to make recommendations for use in risk assessments. For oral exposure (ingestion) we recommend using the Toxic Equivalent Factor (TEF) method and the unit risk estimate (URE o) of 0.2 (mg/kg/d) -1 established by the Netherlands Environmental Assessment Agency, as proposed by AFSSA (Agence française de sécurité sanitaire des aliments). For inhalation, we recommend applying the TEF to the URE i specific for benzo[a]pyrene, ie 1.1.10 -3 (μg/m 3), proposed by the California Office of Health Hazard Assessment. The table established by Nisbet and LaGoy in 1992 is recommended for the TEF, with the following exceptions: use a TEF of 0.001 for non-carcinogenic PAHs and for naphthalene and apply a TEF of 1 instead of 5 to dibenz[a,h]anthracene. These proposals apply to oral and respiratory exposure. In the rare case that a PAH analysis reveals a composition close to that defined by WHO (coking mix), it is preferable to retain the value proposed by WHO of 8.7.10 -2 (μg/m 3) -1, without applying any TEF. Benzo pyrene is then considered to be the indicator of the PAH mixture.
