摘要：Figures See all figures Authors Nathalie Bonvallot , Laurent Bodin , Cédric Duboudin , Denis Bard École des hautes études en santé publique Avenue du professeur Léon Bernard CS 74312, 35043 Rennes cedex, Agence française de sécurité sanitaire de l’environnement et du travail 253, avenue du Général Leclerc 94701 Maisons-Alfort Cedex, Union des caisses nationales de sécurité sociale 18, avenue Léon Gaumont 75980 Paris cedex Key words: BMD, BMDL, critical dose, dose-response models, Human Toxicity Values, risk assessment DOI : 10.1684/ers.2009.0300 Page(s) : 529-37 Published in: 2009 The process of assessing health risks related to chemical compounds believed to have a threshold dose traditionally relies on the derivation of a Toxicity Reference Value (TRV), based most often on the highest no-observed-adverse-effect level (NOAEL) found in experimental animal data, after the application of uncertainty factors. Criticism of the NOAEL approach over the years has led to an alternative method: the benchmark dose (BMD), which is used increasingly today. In this paper we present the methods used to construct a BMD and discuss its fields of application, its advantages and its limitations.
