摘要：Figures Tables Authors Paul Tossa * Thibault Roguet Anne-Charlotte Thoren Aleksandra Piotrowski EDF Service des études médicales 45 rue Kléber 92309 Levallois-Perret cedex France * Tirés à part Key words: nanomaterials, tests, genotoxicity DOI : 10.1684/ers.2014.0684 Page(s) : 113-22 Published in: 2014 The toxicity of nanomaterials, including their genotoxicity, is the object of several research projects across the world. Currently available data on their genotoxicity show high variability in study results as well as complexity associated with the use of the existing methods that makes it difficult to interpret and compare these results. Although some existing genotoxicity evaluation methods can be applied to nanomaterials, they require adaptation, to take the physicochemical specificities of nanomaterials into account. This report of published data in the field of nanogenotoxicology presents some possible mechanisms of this genotoxicity, an evaluation of the methods used in various studies, the factors that influence the results, and some recommendations to enable subsequent studies to control for these factors.
