期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2010
卷号：2
期号：2
页码：106-113
DOI：10.1684/nrp.2010.0065
出版社：John Libbey Eurotext
摘要：Authors Sylvie Belleville , Sylvia Villeneuve , Frédéric Peters , Stéphane Protat Centre de recherche, Institut universitaire de gériatrie de Montréal, Département de psychologie, Université de Montréal, Canada Key words: mild cognitive impairment, vascular burden, vascular dementia, Alzheimer's disease, aging DOI : 10.1684/nrp.2010.0065 Page(s) : 106-13 Published in: 2010 There is increasing evidence for an overlap between the different forms of dementia, in particular dementia of the Alzheimer type and vascular dementia. For example, it is now well established that vascular risk factors are associated with more important cognitive decline in older adults and that they increase their risk of developing not only vascular dementia but Alzheimer's disease as well. Little is known regarding the relation between vascular burden and cognition in persons meeting criteria for mild cognitive impairment. The goal of this article is to present and summarize studies that have examined those issues. Cognitive functions in persons with mild cognitive impairment will be examined as a function of their vascular burden expressed clinically by measuring the number of vascular diseases and risk factors and, expressed neuro-radiologically by measuring the presence and severity of subcortical white matter changes with structural magnetic resonance. We will overview data examining the effect of vascular burden on executive functions, episodic memory and on neuropsychiatric symptoms. This article will also propose a new approach where patients are not distinguished as a function of clinical criteria but rather, as a function of their brain anomalies measured with in vivo brain imaging techniques. Preliminary findings in support of this approach will be presented.
