期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2012
卷号：4
期号：1
页码：60-68
DOI：10.1684/nrp.2012.0200
出版社：John Libbey Eurotext
摘要：Figures See all figures Authors Carine Malle , Cyprien Bourrilhon , Mickaël Laisney , Peggy Quinette , Béatrice Desgranges , Francis Eustache , Christophe Piérard Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France, Inserm, U1077, Caen, France, Université de Caen Basse-Normandie, UMR-S1077, Caen, France, École Pratique des Hautes Études, UMR-S1077, Caen, France, CHU de Caen, U1077, Caen, France Key words: hypoxia, attention, working memory, episodic memory, hippocampus DOI : 10.1684/nrp.2012.0200 Page(s) : 60-8 Published in: 2012 To what extent can a deficit in oxygen, i.e. hypoxia, affect cerebral functioning, and particularly memory? This is the question we attempted to answer in this article. We discussed the two main types of hypoxia, high-altitude-induced hypoxia on the one hand and disease-induced hypoxia on the other hand. A review of literature of the last 30 years allowed us to highlight the main memory systems impaired by these different types of hypoxia, namely working memory and episodic memory. We also distinguished two patterns of memory impairments. Indeed, memory disorders due to high-altitude chronic exposure and to chronic diseases seem to include mostly deficits in attention and learning and/or retrieval strategies, while it is episodic memory that is directly impaired in acute hypoxia, both in cases of abrupt high-altitude exposure and after carbon monoxide poisoning. Whereas oxygen-based treatments definitely improve the outcome of memory disorders in patients submitted to chronic hypoxia, their effectiveness seems limited after acute hypoxia, probably because of the development of irreversible cerebral lesions.
关键词：hypoxia; attention; working memory; episodic memory; hippocampus
