期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2013
卷号：5
期号：2
页码：135-141
DOI：10.1684/nrp.2013.0265
出版社：John Libbey Eurotext
摘要：Figures See all figures Authors Aurore Esquevin , Hélène Raoult , Serge Belliard , Isabelle Corouge , Elise Bannier , Florence Le Jeune , Christian Barillot , Jean-Yves Gauvrit , Jean-Christophe Ferré CHU de Rennes, hôpital Pontchaillou, unité d’imagerie neurofaciale, 2, rue H.-Le-Guilloux, 35033 Rennes, France, Université Rennes 1, campus Beaulieu, Inserm/Inria, Irisa, UMR CNRS 6074, unité/projet visages U746, 35042 Rennes, France, Centre Eugène-Marquis, service de médecine nucléaire, rue de la Bataille-Flandres-Dunkerque, 35042 Rennes, France, CHU de Rennes, hôpital Pontchaillou, service de neurologie, 2, rue H.-Le-Guilloux, 35033 Rennes, France Key words: ASL, principle, dementia, functional ASL DOI : 10.1684/nrp.2013.0265 Page(s) : 135-41 Published in: 2013 Arterial Spin Labeling (ASL) is a new perfusion magnetic resonance imaging (MRI), which is non-invasive, without exogenous contrast agent injection or irradiation. It uses endogenous contrast agent, the magnetically labeled arterial blood protons by radiofrequencies impulsions. It has been developed by means of technological improvement and especially high field MRI and multi-channel head-coils. ASL has now been applied in numerous neurological disorders like vascular disorders, intra-cranial malignancy or dementia. One of the most important ways of research concerns ASL in dementia and its use in clinical practice seems to be close. Thus, ASL sequences are now available in clinical MRI. Lastly, functional ASL is a new activation functional MRI technique that should develop in the near future. Indeed, functional ASL has advantages in comparison with functional MRI, mainly a more accurate location of neuronal activation. The aim of this review is firstly to explain the principle of ASL techniques, secondly to describe its principal clinical and research applications, particularly in dementia and in functional MRI.
