期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2013
卷号：5
期号：4
页码：293-297
DOI：10.1684/nrp.2013.0285
出版社：John Libbey Eurotext
摘要：Figures See all figures Authors Charlotte Bezzina , Claire Rampon Université de Toulouse Paul-Sabatier, UPS, UMR5169 CNRS, centre de recherches sur la cognition animale, 118, route de Narbonne, 31062 Toulouse cedex 4, France Key words: environmental enrichment, physical activity, memory, hippocampus, adult neurogenesis, transgenic mice DOI : 10.1684/nrp.2013.0285 Page(s) : 293-7 Published in: 2013 The concept of cognitive and neural reserve has been used to account for the discrepancy between the degree of brain damage and cognitive performances of Alzheimer's disease (AD) patients. This reserve, built on regular participation in educational or leisure activities, has been linked to a reduced risk of AD-related pathology. In order to identify the neurobiological substrates underlying this reserve, murine models have largely been used. Indeed, AD transgenic mice models exhibit, after environmental enrichment exposure, a delayed progression of the pathology, measurable at both cognitive and anatomical levels. Thus, the environmental enrichment paradigm seems to be appropriate to study neural processes involved in the cognitive reserve. Recent studies have analyzed these processes at the cellular and molecular levels, suggesting in particular, that hippocampal adult neurogenesis could be involved.
