摘要：Here we report the effects of subchronic 3, 4-methylene - dioximethamphetamine (MDMA) on the elevated plus- maze, a widely used animal model of anxiety. Rats ex - posed to a mild chronic stress (MCS) protocol received intracerebroventricular microinjections of the selective serotonin reuptake inhibitor (SSRI) – fluoxetine (2.0 ug/ ul) or MDMA, (2.0 ug/ul) for seven days. On the eighth day rats were tested in the elevated plus-maze. Our re - sults showed that sub-chronic MDMA interacted with MCS leading to a decrease in anxiety-related behaviors including: percentage of open arms entries ( F [2, 26] = 4.00; p = 0.031), time spent in the open arms ( F [2, 26] = 3.656; p = 0.040) and time spent in the open arms extremities ( F [2, 26] = 5.842; p = 0.008). These results suggest a po - tential effect of MDMA in the reversion of the emotional significance of aversive stimuli.
其他摘要：Here we report the effects of subchronic 3, 4-methylene - dioximethamphetamine (MDMA) on the elevated plus- maze, a widely used animal model of anxiety. Rats ex - posed to a mild chronic stress (MCS) protocol received intracerebroventricular microinjections of the selective serotonin reuptake inhibitor (SSRI) – fluoxetine (2.0 ug/ ul) or MDMA, (2.0 ug/ul) for seven days. On the eighth day rats were tested in the elevated plus-maze. Our re - sults showed that sub-chronic MDMA interacted with MCS leading to a decrease in anxiety-related behaviors including: percentage of open arms entries ( F [2, 26] = 4.00; p = 0.031), time spent in the open arms ( F [2, 26] = 3.656; p = 0.040) and time spent in the open arms extremities ( F [2, 26] = 5.842; p = 0.008). These results suggest a po - tential effect of MDMA in the reversion of the emotional significance of aversive stimuli.
