摘要:Typhoid fever, otherwise known as enteric fever is a disease, prevalent in the world over and continues to be a major public health concern in most developing countries of the world, especially Africa. The aim of the study was to investigate the effect of climatic variability on typhoid fever prevalence in Sunyani, Ghana. Data for the study were collected from the Out-Patient Department (OPD) of the Sunyani Municipal Hospital from January 2008 to December 2011. This was augmented with data collected from the GEONETCast Centre from the University of Energy and Natural Resources, Sunyani-Ghana over the same period. Both records were retrieved between January and June, 2013. Analysis of the results from the data collected showed that, in the year 2008, the rainfall pattern declined from August (76 mm) to November (38 mm). Within this period, the number of typhoid reported cases increased marginally from 8-14. Surprisingly, although there were no appreciable increase in the pattern of rainfall from November to December, the number of reported cases at the hospital shot up exponentially from 14-114 cases. The number of reported cases of laboratory confirmed Salmonella typhi infection patients who reported at the OPD section of the Municipal Hospital increased from 30 in March to 105 in August. This was accompanied with a rainfall pattern increase over the period from 15-110 mm. Results from this study has shown that, periods of extended rainfall patterns have also not helped to reduce the prevalence of Salmonella typhi infection. In addition, it was also realized that, extended periods of rainfall recorded between January 2008 and December, 2011 has increased the prevalence of the disease in Sunyani Metropolis. Results from this study have shown that, extended periods of rainfall recorded between January 2008 and December, 2011 has increased the prevalence of the disease in Sunyani Metropolis.