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  • 标题:Assays of different aspects of haemostasis – what do they measure?
  • 本地全文:下载
  • 作者:Nahreen Tynngård ; Tomas L Lindahl ; Sofia Ramström
  • 期刊名称:Thrombosis Journal
  • 印刷版ISSN:1477-9560
  • 电子版ISSN:1477-9560
  • 出版年度:2015
  • 卷号:13
  • 期号:1
  • 页码:8
  • DOI:10.1186/s12959-015-0036-2
  • 语种:English
  • 出版社:BioMed Central
  • 摘要:

    Haemostasis is a complex process affected by many factors including both cellular and plasma components. It is a multistep process starting with platelet adhesion to damaged endothelium and ending in clot fibrinolysis. There are several methods available to study different aspects of haemostasis including adhesion, aggregation, coagulation and fibrinolysis. This review describes the different methods, what aspects of haemostasis they measure and their limitations. Methods discussed include methods to study adhesion (e.g. PFA-100, cone and platelet(let) analyzer and perfusion chambers) and aggregation (e.g. Multiplate, VerifyNow and Plateletworks). Furthermore the principles behind viscoelastic haemostatic assays are presented as well as methods that can analyse aspects of haemostasis in plasma or platelet-rich-plasma samples (thrombin generation, overall haemostasis potential and Thrombodynamics Analyzer).

  • 关键词:Coagulation; Haemostasis; Platelets; Coagulation assays; Platelet function testing
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