The authors report on their experience with the adoption of interdisciplinary activities in the teaching-learning process at the Dentistry School of Severino Sombra University (USS), promoted through the Pró-Saúde project. The study describes the stages in developing the proposal, the methodology, difficulties and resistance, and the results and spinoffs. The authors conclude that interdisciplinary activities can be applied to a higher education project as long as the teaching project has guidelines, a faculty body committed to the methodological innovation, and institutional policymakers dedicated to implementing the changes.