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  • 标题:Malaria vaccines: lessons from field trials
  • 本地全文:下载
  • 作者:Struchiner, Claudio J. ; Halloran, M. Elizabeth ; Brunet, Robert C.
  • 期刊名称:Cadernos de Saúde Pública
  • 印刷版ISSN:0102-311X
  • 电子版ISSN:1678-4464
  • 出版年度:1994
  • 卷号:10
  • 页码:S310-S326
  • DOI:10.1590/S0102-311X1994000800009
  • 语种:English
  • 出版社:Escola Nacional de Saúde Pública,Fundação Oswaldo Cruz
  • 摘要:

    Malaria vaccine candidates have already been tested and new trials are being carried out. We present a brief description of specific issues of validity that are relevant when assessing vaccine efficacy in the field and illustrate how the application of these principles might improve our interpretation of the data being gathered in actual malaria vaccine field trials. Our discussion assumes that vaccine evaluation shares the same general principles of validity with epidemiologic causal inference, i.e., the process of drawing inferences from epidemiologic data aiming at the identification of causes of diseases. Judicious exercise of these principles indicates that, for meaningful interpretation, measures of vaccine efficacy require definitions based upon arguments conditional on the amount of exposure to infection, and specification of the initial and final states in which one believes the effect of interest takes place.

  • 关键词:Malária;Vacina;Eficácia da Vacina;Ensaio de Campo
  • 其他关键词:Malaria;Vaccine;Vaccine Efficacy;Field Trial
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