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  • 标题:Economic impact of pneumococcal conjugate vaccination in Brazil, Chile, and Uruguay
  • 本地全文:下载
  • 作者:Constenla, Dagna O.
  • 期刊名称:Revista Panamericana de Salud Pública
  • 印刷版ISSN:1020-4989
  • 出版年度:2008
  • 卷号:24
  • 期号:2
  • 页码:101-112
  • DOI:10.1590/S1020-49892008000800004
  • 语种:English
  • 出版社:Organización Panamericana de la Salud
  • 摘要:

    OBJECTIVES: To evaluate the economic impact of vaccination with the pneumococcal 7-valent conjugate vaccine (PCV7) in Brazil, Chile, and Uruguay. METHODS: A decision analytic model was constructed to compare pneumococcal vaccination of children 0-5 years old with no vaccination in Brazil, Chile, and Uruguay. Costs and health outcomes were analyzed from the societal perspective. Vaccine, demographic, epidemiologic, and cost data were incorporated into this economic analysis. RESULTS: At the rate of diphtheria-tetanus-pertussis (DTP) vaccine coverage and a vaccine price of US$ 53 per dose, PCV7 was projected to prevent 23 474 deaths per year in children under 5 years old in the three countries studied, thus averting 884 841 disability-adjusted life years (DALYs) yearly. To vaccinate the entire birth cohort of the three countries, total vaccine costs would be US$ 613.9 million. At US$ 53 per dose, the cost per DALY averted from a societal perspective would range from US$ 664 (Brazil) to US$ 2 019 (Chile). At a cost of US$ 10 per dose, vaccine cost is lower than the overall cost of illness averted (US$ 125 050 497 versus US$ 153 965 333), making it cost effective and cost-saving. CONCLUSIONS: The results of this study demonstrate that the incorporation of PCV7 vaccine at US$ 53 per dose confers health benefits at extra costs. It is unclear whether vaccination at the current price is affordable to these countries.

  • 关键词:Análisis costo-beneficio;vacunación;vacunas neumocócicas;Brasil;Chile;Uruguay
  • 其他关键词:Cost effectiveness;vaccination;pneumococcal vaccines;Streptococcus pneumoniae;Brazil;Chile;Uruguay
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