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  • 标题:Omega-3 fatty acids reduce the development of preneoplasic lesions
  • 本地全文:下载
  • 作者:Henriques, Viviana Teixeira ; Dias, Cristina Maria Ganns Chaves ; Franceschini, Sylvia do Carmo Castro
  • 期刊名称:Revista de Nutrição
  • 印刷版ISSN:1415-5273
  • 电子版ISSN:1678-9865
  • 出版年度:2009
  • 卷号:22
  • 期号:2
  • 页码:237-244
  • DOI:10.1590/S1415-52732009000200006
  • 语种:English
  • 出版社:Revista de Nutrição
  • 摘要:

    OBJECTIVE: The purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats. METHODS: A total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography. RESULTS: The omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28. CONCLUSION: These results suggest that omega-3 may slow the progress of colorectal carcinogenesis.

  • 关键词:Ácidos graxos;Condições pré-cancerosas;Suplementos dietéticos
  • 其他关键词:Fatty acids;Precancerous;Dietary supplements
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