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  • 标题:Late-stage diagnosis of HIV infection in Brazilian children: evidence from two national cohort studies
  • 本地全文:下载
  • 作者:Ramos Jr., Alberto Novaes ; Matida, Luiza Harunari ; Alencar, Carlos Henrique
  • 期刊名称:Cadernos de Saúde Pública
  • 印刷版ISSN:0102-311X
  • 电子版ISSN:1678-4464
  • 出版年度:2013
  • 卷号:29
  • 期号:7
  • 页码:1291-1300
  • DOI:10.1590/S0102-311X2013000700004
  • 语种:English
  • 出版社:Escola Nacional de Saúde Pública,Fundação Oswaldo Cruz
  • 摘要:

    This study analyzed data from two consecutive retrospective cohort samples (1983 to 1998 and 1999 to 2002) of Brazilian children with AIDS (N = 1,758) through mother-to-child-transmission. Late-stage diagnosis (CDC category C) was investigated in relation to the following variables: year of birth, year of HIV diagnosis, and time periods related to changes in government treatment guidelines. Late-stage diagnosis occurred in 731 (41.6%) of cases and was more prevalent in infants under 12 months of age. The rate of late-stage diagnosis decreased from 48% to 36% between the two periods studied. We also observed a reduction in the proportion of late-stage diagnoses and the time lapse between HIV diagnosis and ART initiation. A significant association was found between timely diagnosis and having been born in recent years (OR = 0.62; p = 0.009) and year of HIV diagnosis (OR = 0.72; p = 0.002/OR = 0.62; p < 0.001). Infants under the age of 12 months were more likely to be diagnosed at a late stage than older children (OR = 1.70; p = 0.004). Despite advances, there is a need to improve the effectiveness of policies and programs focused on improving early diagnosis and management of HIV/AIDS.

  • 关键词:HIV;Diagnóstico Tardio;Criança;VIH;Diagnóstico Tardío;Niño
  • 其他关键词:HIV;Delayed Diagnosis;Child
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