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  • 标题:Serum concentrations of vitamin A and oxidative stress in critically ill patients with sepsis
  • 本地全文:下载
  • 作者:Ribeiro Nogueira, C. ; Ramalho, A. ; Lameu, E.
  • 期刊名称:Nutrición Hospitalaria
  • 印刷版ISSN:0212-1611
  • 出版年度:2009
  • 卷号:24
  • 期号:3
  • 页码:312-317
  • 语种:English
  • 出版社:Aula Médica Ediciones
  • 摘要:

    Introduction: Sepsis is one of the main causes of mortality in patients in Intensive Care Units. As a result of the systemic inflammatory response and of the decrease of the aerobic metabolism in sepsis, the oxidative stress occurs. Vitamin A is recognized by the favorable effect that it exerts on the immune response to infections and antioxidant action. Objetive: To bring new elements for reviewing of the nutritional support addressed to critically ill patients with sepsis, with emphasis to vitamin A. Methods: Critically ill patients with sepsis had circulating concentrations of retinol, β-carotene, thiobarbituric acid-reactive substances (TBARS) and C-reactive protein (CRP) measured in Medicosurgical Intensive Care Unit in the city of Rio de Janeiro, Brazil. The patients were divided into two groups: patients who were receiving nutritional support and those without support. At the act of the patient's admission, APACHE II score was calculated. Results: 46 patients were studied (with diet n = 24 and without diet n = 22). Reduced levels of retinol and β-carotene were found in 65.2% and 73.9% of the patients, respectively. Among the patients who presented lower concentrations of CRP it was found higher β-carotene inadequacy (64.8%) and 50% of retinol inadequacy. There was no significant difference as regards retinol, TBARS and APACHE II levels among the patients with and without nutritional support. However, higher levels of CRP (p = 0.001) and lower levels of serum β-carotene (p = 0.047) were found in patients without nutritional support. Conclusions: Septic patients presented an important inadequacy of retinol and β-carotene. The present study bring elements to the elaboration/review of the nutritional protocol directed to the group studied, especially as regards vitamin A intake.

  • 关键词:Sepsis;Retinol;β-caroteno;Vitamina A;Estrés oxidativo;Atención crítica;Proteína C reactiva
  • 其他关键词:Sepsis;Retinol;β-carotene;Vitamin A;Oxidative stress;Critical care;C-reactive protein
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