PURPOSE: to analize the phonological changes resulting from the application of the Multiple Opposition Approach concerning the Percentage of Consonants Correct - Revised (PCC-R), on the number of phonemes that were acquired in the phonological inventory and on the types of generalization. METHOD: the researched group included five subjects with phonological disorders. It was carried out phonological and complementary assessments. The speech data were transcribed and analyzed through the phonological assessment pre and post-treatment. The subjects underwent the treatment based on the Multiple Opposition Approach. RESULTS: an increase in PCC-R, number of acquired phonemes and presence of different types of generalization in the final assessment, which was statistical difference, except the results of the generalization within sound class were not statistical difference in the pos-treatment. CONCLUSION: the Multiple Oppositions Approach was effective for the treatment of Brazilian Portuguese speakers because the model provided changes in the PCC-R, number of acquired phonemes and some generalizations (to lexical items non used during treatment, to another position of the word, inside a sound class and to other sound class).