The purpose of this article is to analyze which were the main topics of interest in the field of scientific research in Information Science during the first decade of the 21st century in Brazil (2000-2009). In order to do this, the content of scientific production published in four of the most important national journals in the field was analyzed, namely: Ciência da Informação, DataGramaZero, Perspectivas em Ciência da Informação, and Transinformação. The methodology applied is based on co-occurrence analysis of keywords and the representation and interpretation of results by analyzing social networks. To provide a frame of interpretation of the results obtained, the thematic areas proposed by the Working Groups of the Associação Nacional de Pesquisa e Pós-Graduação em Ciência da Informação were compared because it is an institutionalized space in which, by consensus, research on Information Science is discussed in Brazil. We conclude that the major research efforts are acquired when this field is studied.