The aim of this study was investigate the relationship between social skills and nicotine dependence. 97 undergraduate smokers from a public university filled out a questionnaire, the Fagerstrom Test for Nicotine Dependence and the Social Skills Inventory (Del Prette & Del Prette, 2001). Among the subjects, 20.61% were considered nicotine dependent. The Analysis of Variance detected higher scores, on average, for Factor F1 (Confrontation with risk) among addicted smokers on SSI. Applying Multivariate Analysis of Variance, only the knowledge area remains associated with the scores of SSI. There might be association between dependence and the F1 factor of the SSI, among students from the health area. New studies are necessary to verify those associations.