摘要：Histone modifications play important roles in dynamic transcription regulation. In mammals, methylation of lysine 4 in histone H3 (H3K4) is associated with open chromatin environment. From functional genomic perspective, the combinations of methylation co-localized marks in lysine residue 4 of histone H3 (H3K4me) are little studied. The genomic patterns of specific H3K4me co-localized peaks are highly conserved. Additionally, the proteins encoded by genes with co-localization peaks in promoter regions have more partners in protein-protein interaction network. We also found the unbalanced base composition, that is, AT nucleotide is preferred in genomic regions with co-localization H3K4me modifications. Gene Ontology enrichment analysis revealed that genes with specific co-localization modifications in promoter regions are function-specific. We also found the PolII level for different combinations are correlated with the differential methyl accumulation of H3K4. Me1me2me3, the triplet for H3K4me, is associated with tissue specificity. This study helps understanding the genomic features of H3K4me co-localization and the role of H3K4me co-localization in function genomic regulation.
