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  • 标题:Effect of Diisopropyl Phosphorofluoridate in Some Aspects of Carbohydrate Metabolism
  • 本地全文:下载
  • 作者:A. K. Chatterjee ; U. Kaveeshwar
  • 期刊名称:Defence Science Journal
  • 印刷版ISSN:0976-464X
  • 出版年度:2013
  • 卷号:41
  • 期号:2
  • 页码:143-147
  • DOI:10.14429/dsj.41.4420
  • 语种:English
  • 出版社:Defence Scientific Information & Documentation Centre
  • 摘要:An acute dose of DFP equivalent to 50 per cent of the LD50 cause glycogenolysis and hyperglycemia in male albino rats. The hyperglycemic effect can atleast be partially suppressed by the administration of insulin. Under sub-acute dose equivalent to 5 per cent of the LD50, there is glycogenolysis but no change is blood glucose. The action of DFP on carbohydrate metabolism seems to be mediated through adrenal gland. DFP also increases the glycolytic rate, suppresses the LDH activity and is hepatotoxic.
  • 关键词:Glycogenolysis ;Hyperglycemia ;Glycolytic rate ;LDH activity
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