摘要：A hypothesis proposed, according to which non-specific purulent-inflammatory processes are mainly caused by disturbances at low-molecular level—i.e. by small molecules originating from microbes (SMOM), while SMOM homeostasis decompensation takes the leading role in complex polyfactorial pathogenesis of sepsis. The hypothesis is logically justified by understanding the reasonableness for creation within the ontogenesis the system of signal molecules, which would serve as mediators for informational exchange between microorganisms and host’s cells. To check this hypothesis we’ve studied blood of 25 healthy donors and 161 patients with various conditions (peritonitis, endocarditis, infections of urinary tract etc.) using Gas chromatography-Mass spectrometry. In all cases we detected SMOMs-fatty acids (hydroxy-acids, branched, unsaturated and cyclopropanoic acids), aldehydes, alcohol’s and phenyl-carbonic substances, that are never normally synthesized by mammals, but are structural components or metabolites of microorganisms. The quantitative and qualitative characteristics of SMOMs varied significantly in patients from those of healthy people. Substances of low molecular weight—that are the structural components of normal endogenous microflora and dominate in blood of healthy people—have disappeared or were present in very low quantities. Meanwhile concentration of bacterial molecules that are rarely found in healthy persons, has increased by 10–100 times. Other SMOMs, never present in healthy people, were also found. The data obtained stand pro the hypothesis on constant presence of SMOMs in blood of healthy and ill individuals and allow to formulate the Concept on Homeostasis of small molecules originating from microbes; serious break up of this homeostasis (decompensation of SMOM homeostasis) serves as inductor of general inflammatory response, septic shock and multisystem organ failure.Keywords: microbial markers, phenylcarbonic compounds, gas chromatography–mass spectrometry, fatty acids, homeostasis, human blood, non-antibiotics, sepsis.
