摘要：Background. Human papillomavirus (HPV) vaccine prevents cervical pre-cancers and cancers caused by HPVtypes 16 and 18. This study provides information on the HPV types detected in cervical cancers of AlaskaNative (AN) women.Methods. Cases of invasive cervical cancer diagnosed in AN women aged 18 and above between 1980 and2007 were identified from the Alaska Native Tumor Registry. A representative formalin-fixed, paraffinembeddedarchived pathology block was retrieved and serially sectioned to allow histologic confirmationof lesion (first and last sections) and PCR testing of intervening sections. Extracted DNA was tested forHPV using Linear Array HPV Genotyping Test (Roche Diagnostics) with additional INNO-LiPA HPVGenotyping Assay (Innogenetics) testing on negative or inadequate specimens. All specimens were tested for aminimum 37 HPV types.Results. Of 62 cervical cancer specimens evaluated, 57 (91.9%) contained one or more HPV types. Thirty-eight(61.2%) cancers contained HPV types 16 or 18, and 18 (29%) contained an oncogenic type other than type16 or 18.Conclusions. Overall, almost two-thirds (61.2%) of the archived cervical cancers had detectible HPV types 16or 18, a finding similar to studies of US women. As expected, a proportion of cancers would not be preventedby the current vaccines. HPV vaccination and cervical cancer screening are important prevention strategiesfor AN women.Keywords: Alaska Native; HPV; cervical cancer; HPV genotypes(Published: 5 August 2013)This paper is part of Supplement 1, 2013, ICCH15 Proceedings. More papers from this Supplement can be found here.Citation: Int J Circumpolar Health 2013, 72: 21115 - http://dx.doi.org/10.3402/ijch.v72i0.21115
