出版社：College of Physical and Engineering Science, University of Guelph, Canada
摘要：Traumatic brain and spinal cord injuries lead to neuron deterioration and ultimately neuronal cavities at the injury site. Synthetic nanoparticle scaffold materials have properties that encourage neuroregeneration; they have little risk of introducing biological pathogens to the system, they have minimal toxicity and they do not trigger a strong immune response. Additionally, their long and tubular structure resembles the natural extracellular matrix. Self-assembling peptide nanofibre scaffolds and carbon nanotubes injected into neuronal cavities promote movement of cells into the cavity and axon extension and connection (Guo et al., 2007). Carbon nanotubes are electrically conductive, which promotes the redevelopment of neuronal circuits (Re, Gregori & Masserini, 2012). Neurons grown in a CNT scaffold have dense axon-dendrite membrane contacts as well as strong action potentiation (Fabbro, Bosi, Ballerini, & Prato, 2012). Nanoparticle scaffolds are promising materials for synthetic neuroregeneration following trauma.
